Drug Standards
Selleck Chemical LLC Lomustine 50mg 13010-47-4 nsc79037, Gleostine, CeeNU, CCNU
Lomustine (nsc79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical MetoclopramIde 10g
A dual 5-HT3 and dopamine D2 receptor antagonist (IC50s = 308 and 483 nM, respectively); inhibits AChE isolated from the human postmortem caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively); oral administration inhibits emesis induced by cisplatin in ferrets (ED50 = 6,170 UG/kg) and apomorphine in dogs (ED50 = 0.45 mg/kg); inhibits apomorphine-induced climbing and stereotypy in mice (ED50s = 2.2 and 6.5 mg/kg, respectively)
Sigma Aldrich Fine Chemicals Biosciences Sodium nitroprusside British Pharmacopoeia (BP) Reference Standard | 13755-38-9 | MFCD00149192 |
Sodium nitroprusside British Pharmacopoeia (BP) Reference Standard | Mol Wt: 297.95 | 13755-38-9 | MFCD00149192 |
Sigma Aldrich Fine Chemicals Biosciences Clioquinol European Pharmacopoeia (EP) Reference Standard | 130-26-7 | MFCD00006787 |
Clioquinol European Pharmacopoeia (EP) Reference Standard | Mol Wt: 305.5 | 130-26-7 | MFCD00006787 |
Medchemexpress LLC N-Acetyl mesalazine | 51-59-2 | 99.9% | C9H9NO4 | 25 MG
N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid. It serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid and can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. This compound is used in the study of diseases such as colitis and colon cancer.
- Solid appearance
- Light brown to brown color
- Molecular weight of 195.17
- Inhibits •OH radical-stimulated DNA base hydroxylation
- Store at 4°C, protect from light
- Store in solvent at -80°C for 6 months or -20°C for 1 month, protect from light
Sigma Aldrich Fine Chemicals Biosciences Alimemazine for system suitability European Pharmacopoeia (EP) Reference Standard | 4330-99-8 |
Alimemazine for system suitability European Pharmacopoeia (EP) Reference Standard | Mol Wt: 373.49 | 4330-99-8 |
Apexbio Technology LLC AUY922 (NVP-AUY922) 747412-49-3 5mg
AUY922 (NVP-AUY922 CAS 747412-49-3) is a synthetic small molecule inhibitor belonging to the resorcinylic isoxazole amide class that selectively targets heat shock protein 90 (HSP90) AUY922 specifically interacts with the ATP-binding site of the HSP90 N-terminal domain disrupting its chaperone-dependent stabilization of client proteins involved in cell proliferation and survival It demonstrates antiproliferative activity against human gastric cancer cells with reported GI50 values ranging approximately from 2 to 40 nmol/L promoting the proteasomal degradation of receptor tyrosine kinases and other relevant client proteins This compound is widely used in preclinical research settings investigating HSP90-dependent signaling pathways in cancer
Apexbio Technology LLC Ganciclovir sodium 107910-75-8 250mg
Ganciclovir sodium is a nucleoside analog antiviral agent that functions primarily by inhibiting viral DNA polymerase thus blocking viral DNA replication It exerts inhibitory activities in vitro against various DNA viruses including human herpesviruses (e g HSV) and adenovirus serotypes Experimental data indicate inhibitory activity against feline herpesvirus type 1 with an IC50 value of approximately 5 2 M Additionally Ganciclovir sodium shows the capacity to cross the blood-brain barrier Common research applications include antiviral pharmacology studies virology-focused experimental assays and investigations of viral etiology
Medchemexpress LLC Norfloxacin | 70458-96-7 | 98.31% | 10 G
Norfloxacin (MK-0366) is a broad-spectrum antibiotic effective against both Gram-positive and Gram-negative bacteria. It operates by inhibiting DNA gyrase and topoisomerase IV, enzymes crucial for bacterial DNA separation, thus hindering cell division. This synthetic chemotherapeutic antibacterial agent is occasionally used for treating common and complicated urinary tract infections.
- Broad-spectrum antibiotic
- Inhibits DNA gyrase and topoisomerase IV
- Active against Gram-positive and Gram-negative bacteria
- Used to treat urinary tract infections
Medchemexpress LLC Porcn-IN-1 | 2036044-77-4 | 99.57% | 410.44 | 1 ML
Porcn-IN-1 is a potent porcupine inhibitor with an IC50 of 0.5±0.2 nM. It potently inhibits the secretion of Wnt3A, confirming its role as a porcupine inhibitor. Porcupine is an enzyme that catalyzes the addition of palmitoleate to a serine residue in Wnt proteins, a process essential for Wnt protein secretion. Porcn-IN-1 is as potent as the clinical compound LGK974 in a cell-based STF reporter gene assay.
- Potent porcupine inhibitor: IC50 of 0.5±0.2 nM.
- Confirmed inhibition: Potently inhibits the secretion of Wnt3A.
- Comparable to clinical compound: As potent as LGK974 in a cell-based STF reporter gene assay.
- Moderate clearance: Demonstrates moderate clearance in human and rat liver microsomes (57 mL/min/kg and 24 mL/min/kg respectively).
- High clearance in mouse microsomes: Exhibits high clearance in mouse microsomes (109 mL/min/kg).
Cayman Chemical EthacrynIc AcId 1g
A loop diuretic with anticancer activity; inhibits the NKCC cotransporter in duck erythrocytes (IC50 = 0.18 mM); inhibits ATP-dependent chloride uptake in rat renal plasma membrane vesicles at 0.3 mM; inhibits GSTP1-1 and GSTA3-3 (IC50s = 4.9 and ~0.4 μM, respectively); inhibits Wnt/β-catenin signaling in a cell-based reporter assay; cytotoxic to primary chronic lymphocytic leukemia cells (IC50 = 8.56 μM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC50s = 45.53, 39.64, and 25.23 μM, respectively); increases tumor growth reduction induced by afatinib or neratinib in a 4T1 murine breast cancer model at 250 μg per day
Medchemexpress LLC Cefpodoxime Proxetil | 87239-81-4 | 10 MG
Cefpodoxime Proxetil is an orally active, broad-spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria. It functions by binding to penicillin-binding proteins (PBPs), inhibiting peptidoglycan synthesis, and interfering with bacterial cell wall biosynthesis.
- Orally active, broad-spectrum third-generation cephalosporin
- Exhibits potent antibacterial activity against Gram-positive and Gram-negative bacteria
- Inhibits peptidoglycan synthesis
- Interferes with bacterial cell wall biosynthesis
- Used to treat skin structure infections
- Used to treat acute otitis media
- Used to treat pharyngitis
- Used to treat tonsillitis
- Used to treat upper respiratory tract infections
- Used to treat urinary tract infections
- Used to treat sexually transmitted diseases
eMolecules 496775-62-3 | Eltrombopag Olamine | Target Molecule | MFCD22380664 | 564.643 | C29H36N6O6 | 0.000 | NCCO.NCCO.CC1=NN(C(=O)\C1=N/Nc1cccc(-c2cccc(c2)C(O)=O)c1O)c1ccc(C)c(C)c1 | 2mg | 711635113
Eltrombopag Olamine | Target Molecule | 496775-62-3 | MFCD22380664 | 564.643 | C29H36N6O6 | 0.000 | NCCO.NCCO.CC1=NN(C(=O)\C1=N/Nc1cccc(-c2cccc(c2)C(O)=O)c1O)c1ccc(C)c(C)c1 | 2mg | 711635113
Apexbio Technology LLC Cefpodoxime Proxetil 87239-81-4 10mM (in 1mL DMSO)
Cefpodoxime Proxetil is an oral prodrug belonging to the third-generation cephalosporin antibiotics After absorption it undergoes enzymatic hydrolysis in vivo converting to the active metabolite cefpodoxime Cefpodoxime exerts antibacterial activity by binding bacterial penicillin-binding proteins (PBPs) and inhibiting peptidoglycan synthesis thus preventing proper cell wall formation and ultimately leading to bacterial growth inhibition Cefpodoxime Proxetil is routinely employed in biomedical research studies to evaluate its antibacterial spectrum pharmacokinetics bioavailability and bacterial resistance mechanisms Additionally researchers utilize this compound for investigating antibacterial potential via in vitro and in vivo experiments with typical IC50 values varying based on bacterial strains and experimental conditions